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【前沿】Cell Stem Cell:有助恢复脊髓功能的干细胞
2010-10-11 09:45   发布范围:公开

瑞典卡罗林斯卡医学院研究人员8日报告说,他们研究发现一类名为室管膜细胞的干细胞不仅可帮助生成更多新的脊髓细胞,还能帮助恢复脊髓功能。这一成果将有助于研究人员寻找治疗人类各种脊髓损伤的新疗法。

研究人员在新一期美国《细胞-干细胞》杂志上介绍说,他们对实验鼠的研究发现,一旦老鼠的骨髓组织受损,存在于骨髓中的室管膜细胞就会被激活,和一些其他类型的细胞一起,促使分化形成更多的新的骨髓细胞,成为生成新骨髓细胞的“主要来源”。   

因此研究人员猜测,也许能够筛选出一种药物,在脊髓受损后,能够有选择地刺激室管膜细胞,使它分化形成更多的支持细胞,少分化疤痕组织细胞,从而更好地帮助受损脊髓恢复功能。(生物谷Bioon.com)

生物谷推荐英文摘要:

Cell Stem Cell doi:10.1016/j.stem.2010.07.014

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
Fanie Barnabé-Heider, Christian G?ritz, Hanna Sabelstr?m, Hirohide Takebayashi, Frank W. Pfrieger, Konstantinos Meletis, Jonas FrisénSee Affiliations

Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.

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